Metabolic endocrine disruptors: Methods for the identification of metabolism disrupting chemicals
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Metabolic endocrine disruptors: Methods for the identification of metabolism disrupting chemicals

Researchers from Utrecht University present current scientific developments on metabolic endocrine disruptors and methods for identifying metabolism‑disrupting chemicals (MDCs) in regulatory toxicology. They outline how metabolic disruption has emerged as a distinct endocrine modality linked to obesity, diabetes, cardiovascular disease and non‑alcoholic fatty liver disease. The seminar draws on results from EU‑funded research, including the EURION cluster, which developed new approaches for identifying endocrine disruptors beyond traditional EATS pathways. The presentation covers advances in method development, pre‑validation and validation, with a focus on adipogenesis and adiposity‑related assays, such as PPAR‑γ transactivation assays and human stem‑cell‑based adipogenesis models. Improvements using automated microscopy and multi‑endpoint analysis are discussed, alongside the integration of in vitro, in silico and weight‑of‑evidence approaches. Outstanding challenges for regulatory uptake are also addressed, including assay validation, mechanistic complexity and variability in biological responses. This seminar is relevant for professionals working in regulatory toxicology, endocrine disruptor assessment, chemical risk assessment and human health research. More: https://echa.europa.eu/science ************** Subscribe to our channel: https://bit.ly/321VQgE Subscribe to our Safer Chemicals Podcast: https://echa.europa.eu/podcasts Subscribe to our news: https://echa.europa.eu/subscribe Follow us on: *LinkedIn: https://www.linkedin.com/company/european-chemicals-agency *X: https://x.com/EU_ECHA *BlueSky: https://bsky.app/profile/echa.europa.eu *Facebook: https://www.facebook.com/EUECHA/ *Instagram: https://www.instagram.com/onehealth_eu/ Visit our website: https://echa.europa.eu/ Disclaimer: Subtitles are generated by YouTube automatically. The subtitles are made available “as is” without any additional check by ECHA or a third party as to their accuracy or linguistic correctness. ECHA does not guarantee that the subtitles correctly reflect what is being said in the video. The subtitles may be subject to inaccuracies or misrepresentation due to the inherent limitations of the algorithms used. ECHA accepts no liability in connection with the use of the subtitles. You agree to use the subtitles at your own risk and shall not hold ECHA responsible for damage you or any third party may suffer in connection to their use.